St. Gregory’s College was originally established as St. Gregory’s Grammar School by the Catholic Archdiocese of Lagos on 12th March, 1882 at Igbosere Road, Lagos. The school shared the same site with St. John’s Evangelist Catholic Infant School and St. Francis Xavier Primary School (now Holy Cross School). These two were established in 1871. The establishment of St. Gregory’s Grammar School was to create a desired alternative to CMS Grammar School and Methodist Boys High School. It became the third secondary school of the 1880s. At its establishment, St. Gregory’s Grammar School had the teachers’ training wing and the Grammar School wing. At the former, teachers were prepared for the examination of the College of Preceptors and teachers’ certificate. In September 1909, King’s College was established by an Act of the British Parliament to provide for the youth of the colony a higher general education than that provided by the existing mission schools, and to prepare them for matriculation examination of the University of London, and to give a useful course of study to qualify for professional life or to enter government or mercantile service. Some students of the existing schools took examinations into King’s College to partake in the new curriculum. In 1927, after securing a large portion of land in the Southwest Ikoyi region of Lagos State, the Catholic Archdiocese of Lagos relocated St. Gregory’s Grammar School and rebranded it as St. Gregory’s College. This gave the students the opportunity to partake in the National Curriculum and their A-Levels studies. In a short time, St. Gregory’s College became the envy of all because of its holistic educational programme. Her students excelled in morals, academics and sports. From 1979 to 2001, St. Gregory’s College (alongside other missionary and private schools) was taken over by the Lagos State Government. The poor management of the school during this period left the school in a sorry state.